Time frame: 
Duration of the project: 01.01.2023-31.12.2026

Tasks:
Research work in the EU Project HORIZON-CL4 2022 “Platform Optimisation to Enable Nanomaterial Safety Assessment for Rapid Commercialisation”:

The work will focus on properties, behaviour and lifecycle of advanced nanomaterials (hybrid nano-carriers, graphene oxide and Q-dots) in complex matrices at sub-micron resolution.

The following issues will be addressed:

• optimization of methodological approaches for the investigation of advanced nanomaterials in biological and environmental fluids, their degradation, aggregation, persistence and biotransformation;
• development of 3D molecule based imaging technique for uptake quantification, monitoring intracellular translocation and trafficking of nanomaterials as well as their co-localisation and interaction with biomolecules  in organs, tissues and cells down to the subcellular level;
• spectroscopic based diagnostic and prediction of adverse effects  induced by advanced nanomaterials & drugs

A variety of imaging techniques, such as laser scanning confocal microscopy, confocal Raman microscopy and space resolved ion beam techniques will be used. ATR-FTIR, NTA, DLS, flow cytometry and AF4 coupled with UV, MALS, RI and CRM complement the imaging methods.

Requirements:

• master in biochemistry, chemistry, and physics or in a related programme;
• experience in vibrational spectroscopy, fluorescence and ion beam techniques is desirable but not obligatory:
• readiness to become acquainted with cell physiology techniques.

Contact person:                 Dr. Irina Estrela-Lopis
                                               e-mail: Irina.Estrela-Lopis@medizin.uni-leipzig.de